HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Chloro-6-methoxypyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Chloro-6-methoxypyrimidine | HCID 1051509 | 101.6% |
Reaction Steps
3.1 g sodiummethanolate was added to 7.2 g 4,6-dichlorpyrimidine in 150 mL methanol at 0° C. The reaction was warmed to RT and stirred additional 3 h. Water and EtOAC were added and the layers were separated. The organic layer was dried and evaporated to give 7.1 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741892B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-62ae386c7fd94610b67171771a086042 |
| Source note | uspto-grants-2014_06 |