反应详情

4.7 mL 33% HBr in acetic acid, 11.4 g bromine in 30 mL acetic acid was added slowly to a stirred solution of 10 g piperidine-4,4-diol in 60 mL acetic acid at RT. The reaction mixture was stirred additional 45 min at ambient temperature and the acetic acid was completely removed under reduced pressure. The residue was dissolved in 200 mL acetone and refluxed for 1 hour, cooled, filtered and washed with acetone and dried to give 15.2 g of the desired product

1. customthe acetic acid was completely removed under reduced pressure
2. dissolutionThe residue was dissolved in 200 mL acetone
3. temperaturerefluxed for 1 hour
4. temperaturecooled
5. filtrationfiltered
6. washwashed with acetone
7. customdried