反应详情

30 g 4-hydrazinocarbonyl-4-methyl-piperidine-1-carboxylic acid tert-butyl ester was refluxed with 150 mL 1,1,1-trimethoxy-2-methyl-propane overnight. The excess of reagent was removed under vacuum and the residue was purified by chromatography on silica gel to give 19 g of the desired product.

1. customThe excess of reagent was removed under vacuum
2. customthe residue was purified by chromatography on silica gel