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Tert-butyl 4-(hydrazinecarbonyl)-4-methylpiperidine-1-carboxylate → 4-(5-Isopropyl-(1,3,4)oxadiazol-2-yl)-4-methyl-piperidine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tert-butyl 4-(hydrazinecarbonyl)-4-methylpiperidine-1-carboxylate | HCID 66678033 | — |
| 溶媒 | 1,1,1-Trimethoxy-2-methylpropane | HCID 40495 | — |
| 生成物 | 4-(5-Isopropyl-(1,3,4)oxadiazol-2-yl)-4-methyl-piperidine-1-carboxylic acid tert-butyl ester | HCID 86686036 | 105.3% |
反応手順
30 g 4-hydrazinocarbonyl-4-methyl-piperidine-1-carboxylic acid tert-butyl ester was refluxed with 150 mL 1,1,1-trimethoxy-2-methyl-propane overnight. The excess of reagent was removed under vacuum and the residue was purified by chromatography on silica gel to give 19 g of the desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08741892B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-6f8b740d41f34358974a24fb4e422016 |
| 出典メモ | uspto-grants-2014_06 |