反应详情

5 g 2-methyl-isonicotinic acid was stirred 24 h at 50° C. in 150 mL 1.3 mol/L HCl in methanol. The solvent was removed and water was added to the residue. The mixture was basified with saturated sodiumhydrogencarbonate solution and extracted with ethylacetate. The organic layer was dried with magnesiumsulfate and evaporated to give 4.5 g of the desired product.

1. customThe solvent was removed
2. additionwater was added to the residue
3. extractionextracted with ethylacetate
4. dry with materialThe organic layer was dried with magnesiumsulfate
5. customevaporated