反应详情

43 mL benzyloxycarbonyl chloride in 135 mL dichlormethane was added to 17.6 g 1-benzyl-2,5-dihydro-1H-pyrrole in 135 mL dichlormethane at 0° C. in 60 min. The mixture was stirred 3 h at RT and washed with saturated sodium hydrogencarbonate solution. The organic layer was dried and evaporated. The residue was purified by chromatography on silica gel (hexane/ethyl acetate: 5/1) to give 19.7 g of the desired product.

1. washwashed with saturated sodium hydrogencarbonate solution
2. customThe organic layer was dried
3. customevaporated
4. customThe residue was purified by chromatography on silica gel (hexane/ethyl acetate: 5/1)