Trimethylsilyl iodide → HCID 86686052, compound

HRID 400454Notes

Reaction equation

HRID 400454 reaction equation
C[Si]([I:5])(C)C.C(OC([N:16]1[CH2:23][C:22]2[O:21][C:20]([CH3:24])=[N:19][C:18]=2[CH2:17]1)=O)C1C=CC=CC=1>C(#N)C>[IH:5].[CH3:24][C:20]1[O:21][C:22]2[CH2:23][NH:16][CH2:17][C:18]=2[N:19]=1

Participants

4

Reactant 2

HCID 85247Trimethylsilyl iodideHCID 86686051HCID 86686051, compound

Product 1

HCID 86686052HCID 86686052, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.6 mL trimethylsilyliodide was added to 400 mg 2-methyl-4,6-dihydro-pyrrolo[3,4-d]oxazole-5-carboxylic acid benzyl ester in 30 mL acetonitrile. The reaction was stirred 4 h at RT. The solvent was removed to give 390 mg of the desired product.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-1b77d1574e5142bda58aae07ff9ebcb4
Source dataset
uspto-grants-2014_06
Patent number
US08741892B2

Reaction notes

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