反应详情

温度

70 °C

1 g 1-benzyl-5-chloro-2,3,6,7-tetrahydro-1H-azepine-4-carbaldehyde hydrochloride was added to 1 g phenylguanidine carbonate salt and 1 g sodium ethanolate in 25 mL ethanol. The reaction was stirred 4 h at 70° C. The mixture was filtered over silica gel and the solvent was removed. The residue was purified by chromatography on silica gel (dichlormethane/MeOH/ammonia: 19/1/0.1) to yield 300 mg of the desired product.

1. filtrationThe mixture was filtered over silica gel
2. customthe solvent was removed
3. customThe residue was purified by chromatography on silica gel (dichlormethane/MeOH/ammonia: 19/1/0.1)