反应详情

33% hydrobromic acid in conc. acetic acid and 1.97 g bromine was added to 5 g 1-benzyl-azepane-4-one in 15 mL conc. acetic acid. The reaction was stirred 2 h at RT and completely concentrated under reduced pressure. The residue was diluted with ethyl acetate and refluxed for 1 h and crystallized with ethyl acetate to give 4 g of the desired product.

1. concentrationcompletely concentrated under reduced pressure
2. additionThe residue was diluted with ethyl acetate
3. temperaturerefluxed for 1 h
4. customcrystallized with ethyl acetate