反应详情

温度

70 °C

6.6 g urea was added to 6 g 5-bromo-azepan-4-one hydrobromide and heated 24 h at 70° C. 4 M aqueous sodium hydroxide was added and the mixture was extracted with chloroform and ethyl acetate. The combined organic layers were evaporated to give 800 mg of the desired product.

1. extractionthe mixture was extracted with chloroform and ethyl acetate
2. customThe combined organic layers were evaporated