HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 400484Generated: October 25, 2026
Hydrazine → 3,5-bis(4-fluorophenyl)-1H-pyrazole
https://huagongshe.com/reaction/400484
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 1,3-Propanedione, 1,3-bis(4-fluorophenyl)- | HCID 73896 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3,5-bis(4-fluorophenyl)-1H-pyrazole | HCID 16105479 | — |
Reaction Steps
3.9 g 1,3-Bis-(4-fluoro-phenyl)-1,3-propandione was dissolved in 45 mL of a solution of 1 N hydrazine in THF and stirred for 2 h at 75° C. The solvent was removed to give 3.6 g of the desired compound. Rt: 1.03 min (method D), (M+H)+: 257
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08741892B2 |
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| Source dataset | uspto-grants-2014_06 |
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| ORD ID | ord-a728c573b75d463ea14b56975bd2d7d7 |
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| Source note | uspto-grants-2014_06 |
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