Ammonia → 5-Amino-1-cyclohexyl-1H-pyrazole-4-carboxamide

HRID 400490Notes

Reaction equation

HRID 400490 reaction equation
[OH:1]O.[NH2:3][C:4]1[N:8]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:15]#[N:16].N>C(O)C>[NH2:3][C:4]1[N:8]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[N:7]=[CH:6][C:5]=1[C:15]([NH2:16])=[O:1]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 784Hydrogen PeroxideHCID 6900055-Amino-1-cyclohexyl-1H-pyrazole-4-carbonitrile

Product 1

HCID 179603635-Amino-1-cyclohexyl-1H-pyrazole-4-carboxamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

18 ml of 30% strength hydrogen peroxide solution are added to a solution of 5-amino-1-cyclohexyl-1H-pyrazole-4-carbonitrile (1.86 g, 9.81 mmol) in a mixture of 73 mi of ethanol and 90 ml of concentrated aqueous ammonia solution at room temperature, and the mixture is stirred at room temperature for 1 h. The nonaqueous solvents are then stripped off in a rotary evaporator. The product precipitates as solids from the remaining mixture and is filtered off with suction, washed with a little water and dried under high vacuum.

Workup

  1. customThe nonaqueous solvents are then stripped off in a rotary evaporator
  2. customThe product precipitates as solids from the remaining mixture
  3. filtrationis filtered off with suction
  4. washwashed with a little water
  5. customdried under high vacuum

Sources & evidence

ORD record
ord-0d654b4eaef941f9b8fe299bda33ca75
Source dataset
uspto-grants-2014_06
Patent number
US08741907B2

Reaction notes

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