反应详情

温度

85 °C

To a solution of ethyl4-iodo-3nitrobenzoate (Compound 30, 9.45 g, 29.4 mmol) in ethyl acetate (200 ml) and tin(II) chloride dehydrate (33.1 g, 147 mmol). Reaction was heated to 85° C. for 1 h, cooled to 25° C., quenched with NaHCO3(S), filtered off white solid, and then organic layer was concentrated in vacuo. The residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes) to yield the title compound as a light yellow solid.

1. customReaction
2. temperaturecooled to 25° C.
3. customquenched with NaHCO3(S)
4. filtrationfiltered off white solid
5. concentrationorganic layer was concentrated in vacuo
6. customThe residue was purified by chromatography on silica gel (0→50% EtOAc-hexanes)