Tert-butyl 4-iodo-6-phenylpyridin-3-ylcarbamate → (4'-Iodo-3,4,5,6-tetrahydro-2H-[1,2]bipyridinyl-5'-yl)carbamic acid tert-butyl ester

HRID 400579Notes

Reaction equation

HRID 400579 reaction equation
[C:1]([O:5][C:6](=[O:20])[NH:7][C:8]1[CH:9]=[CH:10][C:11]([N:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[N:12][CH:13]=1)([CH3:4])([CH3:3])[CH3:2].C(OC(=O)NC1C=NC(C2C=CC=CC=2)=CC=1[I:34])(C)(C)C>>[C:1]([O:5][C:6](=[O:20])[NH:7][C:8]1[C:9]([I:34])=[CH:10][C:11]([N:14]2[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]2)=[N:12][CH:13]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 50999073Tert-butyl 4-iodo-6-phenylpyridin-3-ylcarbamateHCID 60026701Tert-butyl 6-(piperidin-1-yl)pyridin-3-ylcarbamate

Product 1

HCID 60026779(4'-Iodo-3,4,5,6-tetrahydro-2H-[1,2]bipyridinyl-5'-yl)carbamic acid tert-butyl ester

Procedure

The title product was prepared from (3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-yl)carbamic acid tert-butyl ester in the same manner as described in the preparation of (4-iodo-6-phenylpyridin-3-yl)carbamic acid tert-butyl ester.

Sources & evidence

ORD record
ord-fcbc2bc451174145b9c401df778fc444
Source dataset
uspto-grants-2014_06
Patent number
US08741897B2

Reaction notes

Loading…