5-Bromo-7-[2-(2,2-dimethyl-4-trifluoromethyl-[1,3]dioxolan-4-yl)-1,1-dimethylethyl]-2,3-dihydrobenzofuran → 7-(4,4,4-Trifluoro-3-hydroxy-3-hydroxymethyl-1,1-dimethylbutyl)-2,3-dihydrobenzofuran-5-sulfonic acid amide

HRID 400642Notes

Reaction equation

HRID 400642 reaction equation
BrC1C=C(C(C)(C)CC2(C(F)(F)F)COC(C)(C)O2)C2OCCC=2C=1.C[N:27](C)[S:28]([C:31]1[CH:32]=[C:33]([C:40]([CH3:51])([CH3:50])[CH2:41][C:42]([OH:49])([CH2:47][OH:48])[C:43]([F:46])([F:45])[F:44])[C:34]2[O:38][CH2:37][CH2:36][C:35]=2[CH:39]=1)(=[O:30])=[O:29]>>[F:46][C:43]([F:44])([F:45])[C:42]([OH:49])([CH2:47][OH:48])[CH2:41][C:40]([C:33]1[C:34]2[O:38][CH2:37][CH2:36][C:35]=2[CH:39]=[C:31]([S:28]([NH2:27])(=[O:30])=[O:29])[CH:32]=1)([CH3:51])[CH3:50]

Participants

3

Reactant 2

HCID 578099225-Bromo-7-[2-(2,2-dimethyl-4-trifluoromethyl-[1,3]dioxolan-4-yl)-1,1-dimethylethyl]-2,3-dihydrobenzofuranHCID 600266667-(4,4,4-Trifluoro-3-hydroxy-3-hydroxymethyl-1,1-dimethyl-butyl)-2,3-dihydrobenzofuran-5-sulfonic acid dimethylamide

Product 1

HCID 600267407-(4,4,4-Trifluoro-3-hydroxy-3-hydroxymethyl-1,1-dimethylbutyl)-2,3-dihydrobenzofuran-5-sulfonic acid amide

Procedure

7-(4,4,4-Trifluoro-3-hydroxy-3-hydroxymethyl-1,1-dimethylbutyl)-2,3-dihydrobenzofuran-5-sulfonic acid amide was prepared from 5-bromo-7-[2-(2,2-dimethyl-4-trifluoromethyl-[1,3]dioxolan-4-yl)-1,1-dimethylethyl]-2,3-dihydrobenzofuran in the same manner as in the preparation of 7-(4,4,4-trifluoro-3-hydroxy-3-hydroxymethyl-1,1-dimethylbutyl)-2,3-dihydrobenzofuran-5-sulfonic acid dimethylamide.

Sources & evidence

ORD record
ord-eb26850167c24797b937f6d5495b49be
Source dataset
uspto-grants-2014_06
Patent number
US08741897B2

Reaction notes

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