反应详情

温度

85 °C

To a suspension of 5-{7-[1,1-dimethyl-2-(2-trifluoromethyloxiranyl)ethyl]-2,3-dihydrobenzofuran-5-yl}pyrimidine (56.0 mg, 0.15 mmol) and 1,5,6,7-tetrahydroindol-4-one (41.6 mg, 0.31 mmol) in 1.0 mL of anhydrous ethanol was added sodium ethoxide solution (0.057 mL, 21 wt. % in ethanol). The reaction mixture was heated at 85° C. for 15 hours. After cooling to room temperature, the reaction mixture was concentrated onto silica gel (for dry loading) and purified by silica gel chromatography (eluted with 40% to 70% ethyl acetate-hexanes) to give 42.0 mg (55% yield) of the title compound as a white solid, m.p. 213° C.-214° C.

1. temperatureAfter cooling to room temperature
2. concentrationthe reaction mixture was concentrated onto silica gel (for dry loading)
3. custompurified by silica gel chromatography (eluted with 40% to 70% ethyl acetate-hexanes)