HCID 178426390, compound → HCID 178426648, compound

HRID 400722Notes

Reaction equation

HRID 400722 reaction equation
[OH:1][N:2]=[C:3]([C:5]1[CH:13]=[CH:12][C:8]2[NH:9][CH:10]=[N:11][C:7]=2[CH:6]=1)[NH2:4].[CH3:14]C1C2NC=NC=2C=C(C#N)C=1>>[OH:1][N:2]=[C:3]([C:5]1[CH:13]=[C:12]([CH3:14])[C:8]2[NH:9][CH:10]=[N:11][C:7]=2[CH:6]=1)[NH2:4]

Participants

3

Reactant 2

HCID 178426390HCID 178426390, compoundHCID 178513241N'-hydroxy-3H-benzimidazole-5-carboximidamide

Product 1

HCID 178426648HCID 178426648, compound

Procedure

The title compound was prepared following the procedure described for Intermediate 1, step 2, but starting from 7-methyl-1H-benzimidazole-5-carbonitrile obtained in step 2 (900 mg; 5.73 mmol) as a beige solid (985 mg, 90%). 1H NMR (DMSO-d6) δ 12.60 (br s, 1H), 9.46 (s, 1H), 8.29-7.57 (m, 3H), 5.76 (s, 2H), 2.51 (m, 3H). LC/MS (Method B): 191.1 (M+H)+.

Sources & evidence

ORD record
ord-2365965f66614fcfb1e437ef2d50b885
Source dataset
uspto-grants-2014_06
Patent number
US08741923B2

Reaction notes

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