HuagongsheHuagongshe Chemistry Print Report · For research reference only
ethyl 5-cyano-6-methoxy-1H-indole-2-carboxylate → ethyl 5-[amino(hydroxyimino)methyl]-6-methoxy-1H-indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ethyl 5-cyano-6-methoxy-1H-indole-2-carboxylate | HCID 67401331 | — |
| Reactant | N'-hydroxy-3H-benzimidazole-5-carboximidamide | HCID 178513241 | — |
| Product | ethyl 5-[amino(hydroxyimino)methyl]-6-methoxy-1H-indole-2-carboxylate | HCID 76787425 | — |
Reaction Steps
The title compound was prepared following procedure described for Intermediate 1, step 2, but starting from ethyl 5-cyano-6-methoxy-1H-indole-2-carboxylate obtained in step 1 (120 mg; 0.49 mmol) as a beige solid (135 mg, 99%). 1H NMR (DMSO-d5) δ 9.25 (s, 1H), 7.60 (s, 1H), 7.11 (s, 1H), 6.90 (s, 1H), 5.53 (bs, 2H), 4.31 (q, J=7 Hz, 2H), 3.80 (s, 3H), 1.32 (t, J=7 Hz, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08741923B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-90e2d9327ce9446d99bdadfd86cadbe0 |
| Source note | uspto-grants-2014_06 |