Potassium tert-butoxide → HCID 178441781, compound

HRID 400944Notes

Reaction equation

HRID 400944 reaction equation
[C:1]([C:5]1[N:6]=[C:7]([N:14]2[CH2:17][C:16]([CH2:20][OH:21])([CH2:18]Cl)[CH2:15]2)[C:8]2[N:13]=[N:12][NH:11][C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2].CC(C)([O-])C.[K+]>C1COCC1>[C:1]([C:5]1[N:6]=[C:7]([N:14]2[CH2:17][C:16]3([CH2:20][O:21][CH2:18]3)[CH2:15]2)[C:8]2[N:13]=[N:12][NH:11][C:9]=2[N:10]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 178441793HCID 178441793, compound

Product 1

HCID 178441781HCID 178441781, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of (1-(5-tert-butyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)-3-(chloromethyl)azetidin-3-yl)methanol (284 mg, 915 μmol) (example 179, step 2) and potassium tert-butoxide (205 mg, 1.83 mmol) in THF (3 mL) at 0° C. was stirred to room temperature and stirred for 20 h. The mixture was filtered, concentrated in vacuo and used without further purification in the consecutive step.

Workup

  1. stirringstirred for 20 h
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated in vacuo
  4. customused without further purification in the consecutive step

Sources & evidence

ORD record
ord-c5e2dfe191b643b4b36a6f33b284d97d
Source dataset
uspto-grants-2014_06
Patent number
US08741906B2

Reaction notes

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