O-Methylhydroxylamine hydrochloride → HCID 59762340, compound

HRID 40110Notes

Reaction equation

HRID 40110 reaction equation
[C:1]([C:4]1[N:5]([CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)[C:6]2[C:11]([C:12]=1[C:13]([NH:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[C:19]([F:24])[CH:18]=1)=[O:14])=[CH:10][CH:9]=[C:8]([O:25][CH:26]([CH3:28])[CH3:27])[CH:7]=2)(=O)[CH3:2].[CH3:36][O:37][NH2:38].Cl>>[F:24][C:19]1[CH:18]=[C:17]([CH:22]=[CH:21][C:20]=1[F:23])[CH2:16][NH:15][C:13]([C:12]1[C:11]2[C:6](=[CH:7][C:8]([O:25][CH:26]([CH3:27])[CH3:28])=[CH:9][CH:10]=2)[N:5]([CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)[C:4]=1/[C:1](=[N:38]/[O:37][CH3:36])/[CH3:2])=[O:14]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 597623482-Acetyl-N-(3,4-difluorobenzyl)-6-isopropoxy-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamide2×

Product 1

HCID 59762340HCID 59762340, compound

Procedure

The title compound was prepared from 2-acetyl-N-(3,4-difluorobenzyl)-6-isopropoxy-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxamide (Compound 109) and MeONH2.HCl by General Procedure Q.

Sources & evidence

ORD record
ord-4b5cf8192c91434b8024d312461788c9
Source dataset
uspto-grants-2013_09
Patent number
US08524917B2

Reaction notes

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