Ethyl pivaloylacetate → HCID 59762316, compound

HRID 40111Notes

Reaction equation

HRID 40111 reaction equation
C(O[C:4](=[O:12])[CH2:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8])C.[F:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1[F:22])[CH2:17][NH2:18]>C1(C)C=CC=CC=1>[F:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1[F:22])[CH2:17][NH:18][C:4](=[O:12])[CH2:5][C:6](=[O:11])[C:7]([CH3:8])([CH3:9])[CH3:10]

Participants

4

Reactant 2

HCID 86950Ethyl pivaloylacetateHCID 1235723,4-Difluorobenzylamine

Product 1

HCID 59762316HCID 59762316, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of ethyl4,4-dimethyl-3-oxopentanoate (Alfa Aesar, 2.4 g, 14 mmol) and 3,4-difluorobenzylamine (Aldrich, 2.0 g, 14 mmol) in toluene (15 ml) was refluxed for 24 h. The solvent was removed to yield the title compound as an off-white wax. Used without further purification.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-4090e64e81ec48f2b06db4c1944b633c
Source dataset
uspto-grants-2013_09
Patent number
US08524917B2

Reaction notes

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