HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl pivaloylacetate → N-(3,4-Difluorobenzyl)-4,4-dimethyl-3-oxopentanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl pivaloylacetate | HCID 86950 | — |
| Reactant | 3,4-Difluorobenzylamine | HCID 123572 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(3,4-Difluorobenzyl)-4,4-dimethyl-3-oxopentanamide | HCID 59762316 | — |
Reaction Steps
A solution of ethyl4,4-dimethyl-3-oxopentanoate (Alfa Aesar, 2.4 g, 14 mmol) and 3,4-difluorobenzylamine (Aldrich, 2.0 g, 14 mmol) in toluene (15 ml) was refluxed for 24 h. The solvent was removed to yield the title compound as an off-white wax. Used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524917B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-4090e64e81ec48f2b06db4c1944b633c |
| Source note | uspto-grants-2013_09 |