1-Bromo-2,4-difluorobenzene → 1-(2,4-Difluorophenyl)-2-phenylethanone

HRID 401155Notes

Reaction equation

HRID 401155 reaction equation
C1(C2C=CC=CC=2)C=CC([C:7](=[O:15])[CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=CC=1.Br[C:23]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:24]=1[F:30]>>[F:30][C:24]1[CH:25]=[C:26]([F:29])[CH:27]=[CH:28][C:23]=1[C:7](=[O:15])[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 676741-Bromo-2,4-difluorobenzeneHCID 748171-(1,1'-Biphenyl)-4-yl-2-phenylethan-1-one

Product 1

HCID 431600031-(2,4-Difluorophenyl)-2-phenylethanoneYield 19%

Procedure

Prepared following the procedure described in Intermediate 14, starting from 1-bromo-2,4-difluorobenzene, where the crude product was purified by column chromatography (PE:EtOAc=50:1) to afford Intermediate 21 (250 mg, yield 19%).

Workup

  1. customPrepared
  2. customwas purified by column chromatography (PE:EtOAc=50:1)

Sources & evidence

ORD record
ord-5fa0c77ffddc415a9797884ffeda380f
Source dataset
uspto-grants-2014_06
Patent number
US08741915B2

Reaction notes

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