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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 401155Generated: October 29, 2026

1-Bromo-2,4-difluorobenzene → 1-(2,4-Difluorophenyl)-2-phenylethanone

https://huagongshe.com/reaction/401155

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2,4-difluorobenzeneHCID 67674—
Reactant1-(1,1'-Biphenyl)-4-yl-2-phenylethan-1-oneHCID 74817—
Product1-(2,4-Difluorophenyl)-2-phenylethanoneHCID 4316000319%

Reaction Steps

Prepared following the procedure described in Intermediate 14, starting from 1-bromo-2,4-difluorobenzene, where the crude product was purified by column chromatography (PE:EtOAc=50:1) to afford Intermediate 21 (250 mg, yield 19%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08741915B2
Source datasetuspto-grants-2014_06
ORD IDord-5fa0c77ffddc415a9797884ffeda380f
Source noteuspto-grants-2014_06