反应详情

A mixture of 3-bromo-5-ethoxy-4-hydroxybenzaldehyde (200 mg, 0.82 mmol) and copper (I) cyanide in DMF (5 mL) was refluxed overnight. The reaction mixture was diluted with water (20 mL), extracted with EtOAc, dried over Na2SO4, and concentrated under reduced pressure. Purified by column chromatography on silica gel to afford Intermediate 51 (70 mg, yield 45%).

1. temperaturewas refluxed overnight
2. extractionextracted with EtOAc
3. dry with materialdried over Na2SO4
4. concentrationconcentrated under reduced pressure
5. customPurified by column chromatography on silica gel