1-Bromo-4-fluorobenzene → 1-(4-Fluorophenyl)-2-(thiophen-3-yl)ethanone

HRID 401185Notes

Reaction equation

HRID 401185 reaction equation
C1(C2C=CC=CC=2)C=CC(C(=O)CC2C=CC=CC=2)=CC=1.[C:22]1([C:28](=[O:35])[CH2:29][C:30]2[CH:34]=[CH:33][S:32][CH:31]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.BrC1C=CC([F:43])=CC=1>>[F:43][C:25]1[CH:26]=[CH:27][C:22]([C:28](=[O:35])[CH2:29][C:30]2[CH:34]=[CH:33][S:32][CH:31]=2)=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 99931-Bromo-4-fluorobenzeneHCID 748171-(1,1'-Biphenyl)-4-yl-2-phenylethan-1-oneHCID 122331131-Phenyl-2-(thiophen-3-yl)ethanone2×

Product 1

HCID 610540541-(4-Fluorophenyl)-2-(thiophen-3-yl)ethanoneYield 45%

Procedure

Followed the procedure described in synthesis of Intermediate 14 using N-methoxy-N-methyl-2-(thiophen-3-yl)acetamide (prepared in Step 1 of Intermediate 2) and 1-bromo-4-fluorobenzene to give Intermediate 54, (260 mg, 45%).

Sources & evidence

ORD record
ord-0370a4303a734f1ea72fd26b48ac950a
Source dataset
uspto-grants-2014_06
Patent number
US08741915B2

Reaction notes

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