HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 401196Generated: October 25, 2026
Dimethylformamide → Isoquinoline-6-carbonitrile
https://huagongshe.com/reaction/401196
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 6-Bromoisoquinoline | HCID 313681 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Water | HCID 962 | — |
| Product | Isoquinoline-6-carbonitrile | HCID 23130705 | — |
Reaction Steps
Under N2, a mixture of 6-bromoisoquinoline (400 mg, 1.9 mmol), Zn(CN)2 (446 mg, 3.8 mmol) and Pd(PPh3)4 (40 mg) in DMF (20 mL) was stirred at 100° C. for 1 hour. Cooled the mixture to room temperature and dissolved in water. Followed standard aqueous/EtOAc workup and purified by column chromatography (PE: EtOAc=10:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08741915B2 |
|---|
| Source dataset | uspto-grants-2014_06 |
|---|
| ORD ID | ord-284b5dd0b8694a65b3652234ac78ba22 |
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| Source note | uspto-grants-2014_06 |
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