反应详情

温度

100 °C

Under N2, a mixture of 6-bromoisoquinoline (400 mg, 1.9 mmol), Zn(CN)2 (446 mg, 3.8 mmol) and Pd(PPh3)4 (40 mg) in DMF (20 mL) was stirred at 100° C. for 1 hour. Cooled the mixture to room temperature and dissolved in water. Followed standard aqueous/EtOAc workup and purified by column chromatography (PE: EtOAc=10:1).

1. temperatureCooled the mixture to room temperature
2. customFollowed standard aqueous/EtOAc workup and purified by column chromatography (PE: EtOAc=10:1)