Isovanillin → 4-Methoxy-3-(2-methoxy-ethoxy)-benzaldehyde

HRID 401211Notes

Reaction equation

HRID 401211 reaction equation

OC1[C:9]([O:10][CH2:11]CC)=[CH:8]C(C=O)=CC=1[N+]([O-])=O.[OH:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][C:25]=1[O:26][CH3:27])[CH:21]=[O:22]>>[CH3:27][O:26][C:25]1[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][C:18]=1[O:17][CH2:8][CH2:9][O:10][CH3:11]

Participants

3

Reactant 2

HCID 12127Isovanillin

HCID 573549704-Hydroxy-3-nitro-5-propoxybenzaldehyde

Product 1

HCID 64846574-Methoxy-3-(2-methoxy-ethoxy)-benzaldehydeYield 89%

Procedure

Followed the procedure described in Step 2 of Intermediate 65 starting from 3-hydroxy-4-methoxybenzaldehyde, isolated 2.4 g, yield 89%.

Workup

customisolated 2.4 g, yield 89%

Sources & evidence

ORD record: ord-aded3f5c37f24d268f15923990a7fd19
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08741915B2

Reaction notes

Loading…