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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40129Generated: October 26, 2026

4-iodotetrahydro-2H-pyran → 1-Benzyl-N-(3,4-difluorobenzyl)-2-isopropyl-6-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-3-carboxamide

https://huagongshe.com/reaction/40129

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-iodotetrahydro-2H-pyranHCID 2795506—
Reactant1-Benzyl-N-(3,4-difluorobenzyl)-6-hydroxy-2-isopropyl-1H-indole-3-carboxamideHCID 25160740—
Product1-Benzyl-N-(3,4-difluorobenzyl)-2-isopropyl-6-(tetrahydro-2H-pyran-4-yloxy)-1H-indole-3-carboxamideHCID 59762298—

Reaction Steps

The title compound was prepared from 1-benzyl-N-(3,4-difluorobenzyl)-6-hydroxy-2-isopropyl-1H-indole-3-carboxamide (Compound 8) and 4-iodotetrahydro-2H-pyran (Maybridge) by General Procedure N.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08524917B2
Source datasetuspto-grants-2013_09
ORD IDord-e9be5647593a4d8d9c1431951e40af9f
Source noteuspto-grants-2013_09