5-(Aminomethyl)-2-(trifluoromethyl)pyridine → 2-Isopropyl-6-methoxy-1-(pyridin-2-ylmethyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-indole-3-carboxamide
Reaction equation
[CH:1]([C:4]1[N:5]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[C:6]2[C:11]([C:12]=1[C:13](O)=[O:14])=[CH:10][CH:9]=[C:8]([O:16][CH3:17])[CH:7]=2)([CH3:3])[CH3:2].[F:25][C:26]([F:36])([F:35])[C:27]1[N:32]=[CH:31][C:30]([CH2:33][NH2:34])=[CH:29][CH:28]=1>>[CH:1]([C:4]1[N:5]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[C:6]2[C:11]([C:12]=1[C:13]([NH:34][CH2:33][C:30]1[CH:31]=[N:32][C:27]([C:26]([F:36])([F:25])[F:35])=[CH:28][CH:29]=1)=[O:14])=[CH:10][CH:9]=[C:8]([O:16][CH3:17])[CH:7]=2)([CH3:3])[CH3:2]Participants
3
Procedure
The title compound was prepared from 2-isopropyl-6-methoxy-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxylic acid (Compound 139) and (6-(trifluoromethyl)pyridin-3-yl)methanamine by General Procedure C.
Sources & evidence
- ORD record
- ord-8d6daeab03c24523a144c5357fabac6a
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08524917B2
Reaction notes
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