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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40133Generated: October 25, 2026

5-(Aminomethyl)-2-(trifluoromethyl)pyridine → 2-Isopropyl-6-methoxy-1-(pyridin-2-ylmethyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-indole-3-carboxamide

https://huagongshe.com/reaction/40133

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Aminomethyl)-2-(trifluoromethyl)pyridineHCID 2737718—
Reactant2-isopropyl-6-methoxy-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxylic acidHCID 59762424—
Product2-Isopropyl-6-methoxy-1-(pyridin-2-ylmethyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-indole-3-carboxamideHCID 59762288—

Reaction Steps

The title compound was prepared from 2-isopropyl-6-methoxy-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxylic acid (Compound 139) and (6-(trifluoromethyl)pyridin-3-yl)methanamine by General Procedure C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08524917B2
Source datasetuspto-grants-2013_09
ORD IDord-8d6daeab03c24523a144c5357fabac6a
Source noteuspto-grants-2013_09