3,4-Difluorobenzylamine → N-(3,4-Difluorobenzyl)-2-isopropyl-1-(pyridin-2-ylmethyl)-6-(pyridin-4-yl)-1H-indole-3-carboxamide
Reaction equation
[CH:1]([C:4]1[N:5]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[C:6]2[C:11]([C:12]=1[C:13](O)=[O:14])=[CH:10][CH:9]=[C:8](OC)[CH:7]=2)([CH3:3])[CH3:2].[F:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][C:33]=1[F:34])[CH2:29][NH2:30].[N:35]1[CH:40]=[CH:39][C:38](B(O)O)=[CH:37][CH:36]=1>>[F:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][C:33]=1[F:34])[CH2:29][NH:30][C:13]([C:12]1[C:11]2[C:6](=[CH:7][C:8]([C:38]3[CH:39]=[CH:40][N:35]=[CH:36][CH:37]=3)=[CH:9][CH:10]=2)[N:5]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[C:4]=1[CH:1]([CH3:3])[CH3:2])=[O:14]Participants
4
Procedure
The title compound was prepared from 2-isopropyl-6-methoxy-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxylic acid (Compound 139), 3,4-difluorobenzylamine, and pyridin-4-ylboronic acid by, in order, General Procedure C, General Procedure L, General Procedure V, and General Procedure W.
Sources & evidence
- ORD record
- ord-f3d990ff6ab6492191dc22ccc59d5137
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08524917B2
Reaction notes
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