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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40142Generated: October 27, 2026

3,4-Difluorobenzylamine → N-(3,4-Difluorobenzyl)-2-isopropyl-1-(pyridin-2-ylmethyl)-6-(pyridin-4-yl)-1H-indole-3-carboxamide

https://huagongshe.com/reaction/40142

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-DifluorobenzylamineHCID 123572—
Reactant(Pyridin-4-yl)boronic acidHCID 2734379—
Reactant2-isopropyl-6-methoxy-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxylic acidHCID 59762424—
ProductN-(3,4-Difluorobenzyl)-2-isopropyl-1-(pyridin-2-ylmethyl)-6-(pyridin-4-yl)-1H-indole-3-carboxamideHCID 59762398—

Reaction Steps

The title compound was prepared from 2-isopropyl-6-methoxy-1-(pyridin-2-ylmethyl)-1H-indole-3-carboxylic acid (Compound 139), 3,4-difluorobenzylamine, and pyridin-4-ylboronic acid by, in order, General Procedure C, General Procedure L, General Procedure V, and General Procedure W.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08524917B2
Source datasetuspto-grants-2013_09
ORD IDord-f3d990ff6ab6492191dc22ccc59d5137
Source noteuspto-grants-2013_09