3,4-Difluorobenzylamine → 1-Benzyl-N-(3,4-difluorobenzyl)-5-fluoro-2-isopropyl-6-nitro-1H-indole-3-carboxamide

HRID 40146Notes

Reaction equation

HRID 40146 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([F:20])=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=2)[C:10]([C:21]([OH:23])=O)=[C:9]1[CH:24]([CH3:26])[CH3:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:27][C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][C:35]=1[F:36])[CH2:31][NH2:32]>>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([F:20])=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=2)[C:10]([C:21]([NH:32][CH2:31][C:30]2[CH:33]=[CH:34][C:35]([F:36])=[C:28]([F:27])[CH:29]=2)=[O:23])=[C:9]1[CH:24]([CH3:25])[CH3:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1235723,4-DifluorobenzylamineHCID 59762356HCID 59762356, compound2×

Product 1

HCID 597624011-Benzyl-N-(3,4-difluorobenzyl)-5-fluoro-2-isopropyl-6-nitro-1H-indole-3-carboxamide

Procedure

The title compound was prepared from 1-benzyl-5-fluoro-2-isopropyl-6-nitro-1H-indole-3-carboxylic acid (Compound 170) and 3,4-difluorobenzylamine by General Procedure C.

Sources & evidence

ORD record
ord-9ea5ec2fa1d94314a853327d647639a1
Source dataset
uspto-grants-2013_09
Patent number
US08524917B2

Reaction notes

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