Ammonium Hydroxide → HCID 57690674, compound

HRID 401500Notes

Reaction equation

HRID 401500 reaction equation
[CH2:1]([N:8]1[CH:12]=[C:11]([C:13]([C:15]2[C:16](F)=[N:17][CH:18]=[CH:19][CH:20]=2)=[O:14])[N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[NH4+:23]>>[NH2:23][C:16]1[C:15]([C:13]([C:11]2[N:10]=[CH:9][N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH:12]=2)=[O:14])=[CH:20][CH:19]=[CH:18][N:17]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 57690537HCID 57690537, compound

Product 1

HCID 57690674HCID 57690674, compoundYield 30%

Conditions

Temperature
160 °C

Procedure

A microwave vial was charged with (1-benzyl-1H-imidazol-4-yl)(2-fluoropyridin-3-yl)methanone (50 mg, 0.18 mmol) and a saturated aqueous solution of ammonium hydroxide (1 ml). The reaction mixture was heated under microwave irradiation at 160° C. for 25 minutes. The mixture was evaporated to dryness. The residue was and purified on silica gel by flash column chromatography to give the title compound as a solid (15 mg, 30% yield).

Workup

  1. customThe mixture was evaporated to dryness
  2. custompurified on silica gel by flash column chromatography

Sources & evidence

ORD record
ord-5eda59ec00ec4a98b6fa08a26a52b4c2
Source dataset
uspto-grants-2014_06
Patent number
US08741931B2

Reaction notes

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