2-(Chloromethyl)-1,3-oxazole → 2-Isopropyl-6-methoxy-1-(oxazol-2-ylmethyl)-1H-indole-3-carbaldehyde

HRID 40161Notes

Reaction equation

HRID 40161 reaction equation
[CH:1]([C:4]1[NH:5][C:6]2[C:11]([C:12]=1[CH:13]=[O:14])=[CH:10][CH:9]=[C:8]([O:15][CH3:16])[CH:7]=2)([CH3:3])[CH3:2].Cl[CH2:18][C:19]1[O:20][CH:21]=[CH:22][N:23]=1>>[CH:1]([C:4]1[N:5]([CH2:18][C:19]2[O:20][CH:21]=[CH:22][N:23]=2)[C:6]2[C:11]([C:12]=1[CH:13]=[O:14])=[CH:10][CH:9]=[C:8]([O:15][CH3:16])[CH:7]=2)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 219575432-(Chloromethyl)-1,3-oxazoleHCID 597623092-isopropyl-6-methoxy-1H-indole-3-carbaldehyde2×

Product 1

HCID 597623932-Isopropyl-6-methoxy-1-(oxazol-2-ylmethyl)-1H-indole-3-carbaldehyde

Procedure

2-Isopropyl-6-methoxy-1H-indole-3-carbaldehyde (Compound 137, 0.54 g, 2.49 mmol) and 2-(chloromethyl)oxazole (0.58 g, 4.4 mmol) were reacted as described in General Procedure J to give the title compound as an oil.

Sources & evidence

ORD record
ord-30bd3f1e317a4f9bb85a6f93a596445e
Source dataset
uspto-grants-2013_09
Patent number
US08524917B2

Reaction notes

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