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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 40161Generated: October 26, 2026

2-(Chloromethyl)-1,3-oxazole → 2-Isopropyl-6-methoxy-1-(oxazol-2-ylmethyl)-1H-indole-3-carbaldehyde

https://huagongshe.com/reaction/40161

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Chloromethyl)-1,3-oxazoleHCID 21957543—
Reactant2-isopropyl-6-methoxy-1H-indole-3-carbaldehydeHCID 59762309—
Product2-Isopropyl-6-methoxy-1-(oxazol-2-ylmethyl)-1H-indole-3-carbaldehydeHCID 59762393—

Reaction Steps

2-Isopropyl-6-methoxy-1H-indole-3-carbaldehyde (Compound 137, 0.54 g, 2.49 mmol) and 2-(chloromethyl)oxazole (0.58 g, 4.4 mmol) were reacted as described in General Procedure J to give the title compound as an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08524917B2
Source datasetuspto-grants-2013_09
ORD IDord-30bd3f1e317a4f9bb85a6f93a596445e
Source noteuspto-grants-2013_09