反应详情

The title compound was prepared from 3-chloro-4-({[3-chloro-4-(trifluoromethyl)benzyl]amino}carbonyl)benzenesulfonyl chloride (Preparation 38) and 5-amino-1,2,4-thiadiazole in following Method H described for Example 6. The reaction mixture was added to 2M HCl, extracted into ethyl acetate, dried over sodium sulphate, filtered and evaporated. The crude material was purified by column chromatography eluting with DCM:MeOH:AcOH (95:5:0.5) to yield the title compound.

1. extractionextracted into ethyl acetate
2. dry with materialdried over sodium sulphate
3. filtrationfiltered
4. customevaporated
5. customThe crude material was purified by column chromatography
6. washeluting with DCM:MeOH:AcOH (95:5:0.5)