5-Bromopyrimidine → 5-(Piperidin-3-ylmethyl)pyrimidine

HRID 401806Notes

Reaction equation

HRID 401806 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][C:8]2N=CC=CN=2)[CH2:2]1.BrC1[CH:16]=[N:17][CH:18]=[N:19][CH:20]=1.ICC1CCCN(C(OC(C)(C)C)=O)C1>>[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:7][C:8]2[CH:16]=[N:17][CH:18]=[N:19][CH:20]=2)[CH2:2]1

Participants

4

Reactant 3

HCID 783445-BromopyrimidineHCID 20716152Tert-butyl 3-(iodomethyl)piperidine-1-carboxylateHCID 577319452-(Piperidin-3-ylmethyl)pyrimidine

Product 1

HCID 577322225-(Piperidin-3-ylmethyl)pyrimidine

Procedure

Made in an analogue manner to 2-(piperidin-3-ylmethyl)pyrimidine using 5-bromopyrimidine with tert-butyl 3-(iodomethyl)piperidine-1-carboxylate.

Sources & evidence

ORD record
ord-0a75c067ac35475e8570a377a3d85cc6
Source dataset
uspto-grants-2014_06
Patent number
US08741934B2

Reaction notes

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