Acetonitrile → HCID 71269769, compound

HRID 401838Notes

Reaction equation

HRID 401838 reaction equation
[CH3:1][C:2]([CH3:27])([CH3:26])[C:3]#[C:4][C:5]1[S:9][C:8]([C:10]([OH:12])=[O:11])=[C:7]([N:13]([CH:23]([CH3:25])[CH3:24])[C:14]([C@H:16]2[CH2:21][CH2:20][C:19]([CH3:22])=[CH:18][CH2:17]2)=[O:15])[CH:6]=1.C(#N)C.FC(F)(F)C(O)=O>O>[CH3:1][C:2]([CH3:26])([CH3:27])[C:3]#[C:4][C:5]1[S:9][C:8]([C:10]([OH:12])=[O:11])=[C:7]([N:13]([CH:23]([CH3:24])[CH3:25])[C:14]([C@@H:16]2[CH2:21][CH2:20][C:19]([CH3:22])=[CH:18][CH2:17]2)=[O:15])[CH:6]=1

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 6422Trifluoroacetic acidHCID 71269874HCID 71269874, compound

Product 1

HCID 71269769HCID 71269769, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared in a manner similar to Example 5 using acrylic acid 4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester (S) in place of acrylic acid 4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester (R): MS (m/z): 388.0 [M+H]+; HPLC retention time 4.59 min (2-98% acetonitrile: water with 0.05% trifluoroacetic acid).

Sources & evidence

ORD record
ord-5341b0ecc40f4dcda5be451e2be40e76
Source dataset
uspto-grants-2014_06
Patent number
US08741946B2

Reaction notes

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