HCID 23055952, compound → HCID 67254977, compound

HRID 401855Notes

Reaction equation

HRID 401855 reaction equation
[CH2:1]([NH:4][C@@H:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH:6]1[Br:14])[CH:2]=[CH2:3].Br.CC(O)C>CC(OC)(C)C>[BrH:14].[CH2:1]([NH:4][C@@H:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH:6]1[Br:14])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 23055952HCID 23055952, compoundHCID 67254701HCID 67254701, compound

Product 1

HCID 67254977HCID 67254977, compoundYield 263.5%

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Conditions

Temperature
7.5 °C

Procedure

The obtained N-2-Propene-1-yl-2-bromo-(R)-aminoindan (5 g) in 100 ml of MTBE was added to 10 ml of 10% HBr/IPA solution and the reaction mixture was stirred at 5-10° C. for 30 min. The precipitated solid was filtered, washed with MTBE and dried to give 8.7 g of N-2-Propene-1-yl-2-bromo-(R)-aminoindan hydrobromide (90% yield). Mass spectrum: [M+1]+: 252

Workup

  1. filtrationThe precipitated solid was filtered
  2. washwashed with MTBE
  3. customdried

Sources & evidence

ORD record
ord-68e3db8ba0724da18daec6b71b19523a
Source dataset
uspto-grants-2014_06
Patent number
US08741962B2

Reaction notes

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