2,6-Difluorobenzenesulfonyl chloride → HCID 24830786, compound

HRID 401856Notes

Reaction equation

HRID 401856 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][CH:10]=[CH:11][N:12]=2)=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=1.[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:22]=1[S:28](Cl)(=[O:30])=[O:29]>CO>[F:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:22]=1[S:28]([NH:19][C:16]1[CH:17]=[CH:18][C:13]([C:3]2[CH:4]=[C:5]([C:8]3[O:9][CH:10]=[CH:11][N:12]=3)[CH:6]=[CH:7][C:2]=2[CH3:1])=[CH:14][CH:15]=1)(=[O:30])=[O:29]

Participants

4

Reactant 2

HCID 27342712,6-Difluorobenzenesulfonyl chlorideHCID 58992419HCID 58992419, compound

Product 1

HCID 24830786HCID 24830786, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 2′-Methyl-5′-oxazol-2-yl-biphenyl-4-ylamine (c) (30 mg, 0.12 mmol) in MeOH (2 mL) was added 2,6-difluorobenzene sulfonyl chloride (30 μL, 0.22 mmol). The reaction was heated to 80° C. for 2 hr before the solvent was removed. Column chromatography afforded Compound 1 (28 mg, 55%).

Workup

  1. customwas removed

Sources & evidence

ORD record
ord-20509352b5c146ee82fb4b48e0d0714c
Source dataset
uspto-grants-2014_06
Patent number
US08741960B2

Reaction notes

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