Hydrochloric Acid → {2-[5-(4-Benzyloxy-phenyl)-6-butyl-pyridazin-3-yloxy]-ethyl}-diethyl-amine dihydrochloride

HRID 401871Notes

Reaction equation

HRID 401871 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[C:17]([O:25][CH2:26][CH2:27][N:28]([CH2:31][CH3:32])[CH2:29][CH3:30])[N:18]=[N:19][C:20]=2[CH2:21][CH2:22][CH2:23][CH3:24])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:33]>O1CCOCC1>[ClH:33].[ClH:33].[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:16]=[C:17]([O:25][CH2:26][CH2:27][N:28]([CH2:31][CH3:32])[CH2:29][CH3:30])[N:18]=[N:19][C:20]=2[CH2:21][CH2:22][CH2:23][CH3:24])=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53371810{2-[5-(4-Benzyloxy-phenyl)-6-butyl-pyridazin-3-yloxy]-ethyl}-diethyl-amine

Product 1

HCID 67373135{2-[5-(4-Benzyloxy-phenyl)-6-butyl-pyridazin-3-yloxy]-ethyl}-diethyl-amine dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

{2-[5-(4-Benzyloxy-phenyl)-6-butyl-pyridazin-3-yloxy]-ethyl}-diethyl-amine was dissolved in 4.0 M HCl in dioxane and the solvent was evaporated. The resultant salt was washed with ether and dried to provide the title compound (19 mg). LCMS: m/z 435 [M+1]. 1H NMR (400 MHz, CD3OD) δ 7.89 (1H, s), 7.50-7.53 (2H, m), 7.45-7.47 (2H, m), 7.36-7.40 (2H, m), 7.30-7.34 (1H, m), 7.20-7.24 (2H, m), 5.20 (2H, S), 3.74 (2H, t), 3.35-3.42 (4H, m), 3.15 (2H, t), 1.48-1.53 (2H, m), 1.4 (6H, t), 1.21-1.32 (4H, m), 0.81 (3H, t).

Workup

  1. customthe solvent was evaporated
  2. washThe resultant salt was washed with ether
  3. customdried

Sources & evidence

ORD record
ord-c7117cf5c8694470b8cdb3796e168d27
Source dataset
uspto-grants-2014_06
Patent number
US08741900B2

Reaction notes

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