Hydrochloric Acid → HCID 67387349, compound

HRID 401935Notes

Reaction equation

HRID 401935 reaction equation
[CH2:1]([C:5]1[N:10]=[N:9][C:8]([O:11][CH:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH:13]2[CH2:19][OH:20])=[CH:7][C:6]=1[C:21]1[CH:26]=[CH:25][C:24]([O:27][CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:23][CH:22]=1)[CH2:2][CH2:3][CH3:4].[ClH:34]>O1CCOCC1>[ClH:34].[ClH:34].[CH2:1]([C:5]1[N:10]=[N:9][C:8]([O:11][CH:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH:13]2[CH2:19][OH:20])=[CH:7][C:6]=1[C:21]1[CH:22]=[CH:23][C:24]([O:27][CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:25][CH:26]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58438396HCID 58438396, compound

Product 1

HCID 67387349HCID 67387349, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The {4-[6-Butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]-1-methyl-piperidin-3-yl}-methanol was dissolved in 4.0 M HCl in dioxane (2 mL) and evaporated the solvent, dried to provide the title compound (26 mg). LCMS: m/z 455 [M+1]. 1H NMR (400 MHz, CD3OD) δ 7.32 (2H, d), 7.03 (2H, d), 6.99 (1H, s), 5.58 (1H, s), 4.44-4.38 (1H, m), 3.66-3.62 (1H, m), 3.58-3.49 (1H, m), 2.96-2.80 (4H, m), 2.63-2.20 (7H, m), 2.08-1.90 (3H, m), 1.88-1.78 (2H, m), 1.62-1.20 (11H, m), 0.79 (3H, t,).

Workup

  1. customevaporated the solvent
  2. customdried

Sources & evidence

ORD record
ord-afbd02900d824f318c6bb6a0f05f6b02
Source dataset
uspto-grants-2014_06
Patent number
US08741900B2

Reaction notes

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