Hydrochloric Acid → HCID 67372253, compound

HRID 401940Notes

Reaction equation

HRID 401940 reaction equation
[CH2:1]([C:5]1[N:6]=[N:7][C:8]([O:24][CH2:25][CH:26]2[C:31]([F:33])([F:32])[CH2:30][CH2:29][N:28]([CH3:34])[CH2:27]2)=[CH:9][C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH3:4].[ClH:35]>O1CCOCC1>[ClH:35].[ClH:35].[CH2:1]([C:5]1[N:6]=[N:7][C:8]([O:24][CH2:25][CH:26]2[C:31]([F:33])([F:32])[CH2:30][CH2:29][N:28]([CH3:34])[CH2:27]2)=[CH:9][C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]2)=[CH:13][CH:12]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58438409HCID 58438409, compound

Product 1

HCID 67372253HCID 67372253, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-Butyl-4-(4-cyclohexyloxy-phenyl)-6-(4,4-difluoro-1-methyl-piperidin-3-ylmethoxy)-pyridazine was dissolved in 4.0 M HCl in dioxane (2 mL) and evaporated the solvent to provide the title compound (59 mg). LCMS: m/z 475 [M+1]. 1H NMR (400 MHz, CD3OD) δ 7.29 (2H, d), 7.04 (2H, d), 6.97 (1H, s), 4.80 (1H, dd), 4.48-4.36 (2H, m), 3.16-3.06 (1H, m), 2.92-2.86 (3H, m), 2.76-2.60 (1H, m), 2.48-2.32 (5H, m), 2.16-2.04 (2H, m), 2.02-1.98 (2H, m), 1.82-1.78 (2H, m), 1.62-1.20 (10H, m), 0.79 (3H, t).

Workup

  1. customevaporated the solvent

Sources & evidence

ORD record
ord-85c5a63f91fd47cd8695debdb394f538
Source dataset
uspto-grants-2014_06
Patent number
US08741900B2

Reaction notes

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