Hydrochloric Acid → HCID 86657813, compound

HRID 401965Notes

Reaction equation

HRID 401965 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C@@H:11]([CH:14]([F:16])[F:15])[C@H:10]([O:17][C:18]2[N:19]=[N:20][C:21]([CH2:37][CH2:38][CH2:39][CH3:40])=[C:22]([C:24]3[CH:29]=[CH:28][C:27]([O:30][CH:31]4[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]4)=[CH:26][CH:25]=3)[CH:23]=2)[CH2:9]1)=O)(C)(C)C.[ClH:41]>C(Cl)Cl.O1CCOCC1>[ClH:41].[ClH:41].[CH2:37]([C:21]1[N:20]=[N:19][C:18]([O:17][C@H:10]2[C@H:11]([CH:14]([F:16])[F:15])[CH2:12][CH2:13][NH:8][CH2:9]2)=[CH:23][C:22]=1[C:24]1[CH:29]=[CH:28][C:27]([O:30][CH:31]2[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]2)=[CH:26][CH:25]=1)[CH2:38][CH2:39][CH3:40]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86657812HCID 86657812, compound

Product 1

HCID 86657813HCID 86657813, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (±)-trans-3-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]-4-difluoromethyl-piperidine-1-carboxylic acid tert-butyl ester (0.32 mmol, 0.18 g) in DCM (0.75 mL) was added 4 N HCl in dioxane (0.75 mL). The solution was stirred for 1 hour. The solvents were removed with reduced pressure and the salt was triturated with diethyl ether and filtered to give (±)-trans-3-butyl-4-(4-cyclohexyloxy-phenyl)-6-(4-difluoromethyl-piperidin-3-yloxy)-pyridazine dihydrochloride (0.14 g).

Workup

  1. customThe solvents were removed with reduced pressure
  2. customthe salt was triturated with diethyl ether
  3. filtrationfiltered

Sources & evidence

ORD record
ord-fb14a55cf983426fa9496e2805a6d2df
Source dataset
uspto-grants-2014_06
Patent number
US08741900B2

Reaction notes

Loading…