Hydrochloric Acid → HCID 67373638, compound

HRID 401974Notes

Reaction equation

HRID 401974 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[N:16]=[N:17][C:18]([CH2:38][CH2:39][CH2:40][CH3:41])=[C:19]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH:32]4[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]4)=[CH:27][CH:26]=3)[C:20]=2[C:21]([F:24])([F:23])[F:22])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:42]>C(Cl)Cl.O1CCOCC1>[ClH:42].[ClH:42].[CH2:38]([C:18]1[N:17]=[N:16][C:15]([O:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[C:20]([C:21]([F:22])([F:24])[F:23])[C:19]=1[C:25]1[CH:26]=[CH:27][C:28]([O:31][CH:32]2[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]2)=[CH:29][CH:30]=1)[CH2:39][CH2:40][CH3:41]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67375645HCID 67375645, compound

Product 1

HCID 67373638HCID 67373638, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-4-trifluoromethyl-pyridazin-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (0.294 mmol, 0.17 g) in DCM (1 mL) was added 4 N HCl in dioxane (0.5 mL) and the reaction was stirred for 1 hour. The solvents were removed with reduced pressure and the salt was triturated with diethyl ether and filtered to give 3-butyl-4-(4-cyclohexyloxy-phenyl)-6-(piperidin-4-yloxy)-5-trifluoromethyl-pyridazine dihydrochloride (0.12 g).

Workup

  1. customThe solvents were removed with reduced pressure
  2. customthe salt was triturated with diethyl ether
  3. filtrationfiltered

Sources & evidence

ORD record
ord-01a4a8eb081040c8bfb34d9b4de382c1
Source dataset
uspto-grants-2014_06
Patent number
US08741900B2

Reaction notes

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