Hydrochloric Acid → 6-Butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carboxylic acid ((R)-1-ethyl-pyrrolidin-2-ylmethyl)-amide dihydrochloride

HRID 402047Notes

Reaction equation

HRID 402047 reaction equation
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@@H:4]1[CH2:8][NH:9][C:10]([C:12]1[N:13]=[N:14][C:15]([CH2:31][CH2:32][CH2:33][CH3:34])=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)=[CH:20][CH:19]=2)[CH:17]=1)=[O:11])[CH3:2].[ClH:35]>O1CCOCC1.C(Cl)Cl>[ClH:35].[ClH:35].[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@@H:4]1[CH2:8][NH:9][C:10]([C:12]1[N:13]=[N:14][C:15]([CH2:31][CH2:32][CH2:33][CH3:34])=[C:16]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)=[CH:22][CH:23]=2)[CH:17]=1)=[O:11])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 584384156-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carboxylic acid ((R)-1-ethyl-pyrrolidin-2-ylmethyl)-amide

Product 1

HCID 673747316-Butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carboxylic acid ((R)-1-ethyl-pyrrolidin-2-ylmethyl)-amide dihydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

The amide was treated with 2 mL of 4.0 M HCl in dioxane solution in 2 mL of DCM for 1 h to provide the title compound.

Sources & evidence

ORD record
ord-395da1aea5c34c439aa4777b86b7c734
Source dataset
uspto-grants-2014_06
Patent number
US08741900B2

Reaction notes

Loading…