3,5-Dimethylpyrazole → HCID 178487714, compound

HRID 402191Notes

Reaction equation

HRID 402191 reaction equation
C([O:8][C:9]1[C:18]2[C:13](=[C:14]([CH3:21])[C:15]([O:19][CH3:20])=[CH:16][CH:17]=2)[N:12]=[C:11](Cl)[CH:10]=1)C1C=CC=CC=1.[CH3:23][C:24]1[CH:28]=[C:27]([CH3:29])[NH:26][N:25]=1.OC1C2C(=C(C)C(OC)=CC=2)N=C(N2C=CC(C(C)C)=N2)C=1>>[OH:8][C:9]1[C:18]2[C:13](=[C:14]([CH3:21])[C:15]([O:19][CH3:20])=[CH:16][CH:17]=2)[N:12]=[C:11]([N:25]2[C:24]([CH3:23])=[CH:28][C:27]([CH3:29])=[N:26]2)[CH:10]=1

Participants

4

Reactant 3

HCID 62103,5-DimethylpyrazoleHCID 576079364-Benzyloxy-2-chloro-7-methoxy-8-methylquinolineHCID 178487709HCID 178487709, compound

Product 1

HCID 178487714HCID 178487714, compound

Procedure

The title compound was prepared from 4-benzyloxy-2-chloro-7-methoxy-8-methyl-quinoline (63) and 3,5-dimethylpyrazole following the procedure reported for the preparation of 4-hydroxy-2-(3-isopropylpyrazol-1-yl)-7-methoxy-8-methylquinoline (64): m/z=284 (M+H)+.

Sources & evidence

ORD record
ord-75ba862070884ded9ded16d24806ee54
Source dataset
uspto-grants-2014_06
Patent number
US08741926B2

Reaction notes

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